Alzheimer brain its atrophy shrunken and here you seethes inset show you in the frontal lobe and temporal lobe these concentrations of plaques and tangles in fact they're sort region on the medial temporal lobe there's more tangles brain ammo in the frontal lobe in the prior to love this more plaque look at the healthy brain you see an occasional plaque and you see an occasional table turns out that these farinaceous material that define the disease start building up in our brains years even decades before we have symptoms you know get into some the evidence for that in just a moment but let's define a couple other terms and I'm going to be using first memory now %uh memory is a very complex function but to keep it basic we can think of two components to memory learning and recall so we have to learn the information get into our heads and we have to beagle to retrieve it later I also use the term cognition which encompasses memory but other mental brain ammo functions attention thinking reasoning visual spatial skills and the ability tread a map and then there's a term dementia which also many people equate with senility it’s basically memory loss and other cognitive impairment any impairment is to the degree that it interferes with everyday life so people with dementia need help from others and the most common cause of dementia Alzheimer's disease that's where you at the plaques and tangles in the brain there's a gradual onset and progression but many different things can cause to mention you can become demented from having small strokes your brain and their the onset might be Sun or could be a sudden onset from a depression and that can be a treatable
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