Aspirin (USAN), also known as acetylsalicylic acid (INN (/əˌsɛtəlˌsælɨˈsɪlɨk/ ə-SET-əl-SAL-i-SIL-ik) ASA), is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. The active ingredient of Aspirin was first discovered from the bark of the willow tree in 1763 by Edward Stone of Wadham College, Oxford University. He had discovered salicylic acid, the active metabolite of aspirin.[1] Aspirin was first synthesized by Felix Hoffmann, a chemist with the German company Bayer in 1897.[2][3]
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Aspirin also has an antiplatelet effect by inhibiting the production of thromboxane, which under normal circumstances binds platelet molecules together to create a patch over damaged walls of blood vessels. Because the platelet patch can become too large and also block blood flow, locally and downstream, aspirin is also used long-term, at low doses, to help prevent heart attacks, strokes, and blood clot formation in people at high risk of developing blood clots.[5] It has also been established that low doses of aspirin may be given immediately after a heart attack to reduce the risk of another heart attack or of the death of cardiac tissue.[6][7] Aspirin may be effective at preventing certain types of cancer, particularly colorectal cancer
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